γ-Glutamyl Transferase (GGT)
γ-Glutamyl Transferase, Gamma-Glutamyl Transferase
Gamma-glutamyl transferase (GGT) is a membrane-bound enzyme that plays a crucial role in Meister’s γ-glutamyl cycle, catabolizing reduced glutathione into cysteine and glycine. It anchors to the cell membrane via its N-terminus, with catalytic activity in the extracellular domain. GGT can remove the γ-glutamyl group from various extracellular substrates like proteins by cleaving γ-carboxyl bonds of glutamate. This enzyme is vital for glutathione homeostasis and mercapturic acid metabolism. Elevated serum GGT levels are significant markers for liver diseases, such as hepatitis C, cholestatic syndromes, and alcohol-related liver disease, as well as atherosclerotic cardiovascular disease[1].
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γ-Glutamyl Transferase (GGT) Related Products (13)
Related Products (13)
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GGsTop
0 ImagesCat. No.: HY-108467CAS No.: 926281-37-0Synonyms: NahlsgenGGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ-GGT inhibitor, with a Ki of 170 μM for Human GGT. GGsTop shows a pKa of 9.71, also exhibits Kons of 150 and 51 M-1 s-1 against E.coli GGT and human GGT, respectively. GGsTop protects hepatic ischemia-reperfusion injury in rat model.
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Acivicin
0 ImagesSynonyms: AT-125; U-42126Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties.
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FGTI-2734 mesylate
0 ImagesFGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors.
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OU749
0 ImagesOU749 is a potent γ-glutamyl transpeptidase (GGT) inhibitor with a Ki value of 17.6 µM. OU749 shows cytotoxicity.
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L-Glutamic acid γ-(3-carboxy-4-nitroanilide) ammonium salt
0 ImagesSynonyms: L-γ-Glutamyl-3-carboxy-4-nitroanilide ammonium saltL-Glutamic acid γ-(3-carboxy-4-nitroanilide) ammonium salt is a donor substrate of gamma-glutamyltransferase (GGT) that can be used to measure GGT activity.
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C-HBrO-GGT
0 ImagesCat. No.: HY-D3170C-HBrO-GGT is a dual-target fluorescent indicator with specificity for γ-glutamyl transpeptidase (GGT) and hypobromous acid (HBrO). C-HBrO-GGT acts as a substrate for GGT and HBrO, undergoing enzymatic or chemical modification to trigger channel-specific fluorescence, with sequential activation requiring initial GGT hydrolysis. C-HBrO-GGT enables simultaneous in vitro and in vivo fluorescence detection of GGT and HBrO. C-HBrO-GGT identifies mature atherosclerotic plaque positions and provides early warning of plaque formation before visual or classical immunofluorescent detection. C-HBrO-GGT can be used for the research of atherosclerosis (Ex/Em = 370 nm/500 nm).
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Gamma-Glutamyl Transferase-IN-2
0 ImagesCat. No.: HY-154996CAS No.: 2956809-82-6Gamma-Glutamyl Transferase-IN-2 (compound 4dq) is a β-carboline 1-hydrazide inhibitor with antifungal and antibacterial activities, targeting to glutamyltransferase. Gamma-Glutamyl Transferase-IN-2 acts function by resulting the accumulation of reactive oxygen species, destruction of cell membranes, and dysregulation of histone acetylation.
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Gamma-Glutamyl Transferase-IN-1
0 ImagesCat. No.: HY-154993CAS No.: 2956809-71-3Gamma-Glutamyl Transferase-IN-1 (compound 4de) is a β-carboline 1-hydrazide inhibitor with antifungal and antibacterial activities, targeting to glutamyltransferase. Gamma-Glutamyl Transferase-IN-1 acts function by resulting the accumulation of reactive oxygen species, destruction of cell membranes, and dysregulation of histone acetylation.
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Acivicin (Standard)
0 ImagesCat. No.: HY-W016586RCAS No.: 42228-92-2Synonyms: AT-125 (Standard); U-42126 (Standard)Articaine (Standard) is the analytical standard of Articaine. This product is intended for research and analytical applications. Articaine (Hoe-045 free base) is an amide agent that can suppress or relieve pain. containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-κB activation and the NLRP3 inflammasome pathway.
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GGsTop (Standard)
0 ImagesCat. No.: HY-108467RCAS No.: 926281-37-0Synonyms: Nahlsgen (Standard)GGsTop (Standard) is the analytical standard of GGsTop. This product is intended for research and analytical applications. GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ-GGT inhibitor, with a Ki of 170 μM for Human GGT. GGsTop shows a pKa of 9.71, also exhibits Kons of 150 and 51 M-1 s-1 against E.coli GGT and human GGT, respectively. GGsTop protects hepatic ischemia-reperfusion injury in rat model.
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6-Diazo-5-oxo-D-norleucine
0 ImagesCat. No.: HY-W142025CAS No.: 71629-86-26-Diazo-5-oxo-D-norleucine, a D-Glutamine (HY-100587) analog, is a γ-glutamyl transferase inhibitor.
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Acivicin hydrochloride (Standard)
0 ImagesCat. No.: HY-W016586ARCAS No.: 161922-40-3Synonyms: AT-125 hydrochloride (Standard); U-42126 hydrochloride (Standard)Acivicin (hydrochloride) (Standard) is the analytical standard of Acivicin (hydrochloride). This product is intended for research and analytical applications. Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].
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